Should the response to an opioid antagonist is suboptimal or only temporary in nature, administer added antagonist as directed by the solution’s prescribing information and facts. The respiratory depressant effects of promethazine are certainly not reversed by opioid antagonists, for instance naloxone.
Greater strain in your head (increased intracranial force). Avoid using Promethazine Hydrochloride and Codeine Phosphate Oral Option In case you have a head injuries or have already been told that you've got variations from the tissue within your brain (brain lesions) or amplified pressure in your head.
Don't utilize a family teaspoon to evaluate your medicine. You could unintentionally choose an excessive amount. You could ask your pharmacist for that measuring gadget you should use and how to measure the right dose.
All sufferers addressed with opioids demand thorough monitoring for signs of abuse and habit, considering that usage of opioid analgesic and antitussive products carries the chance of addiction even below suitable healthcare use.
are breastfeeding or want to breastfeed. Codeine passes into your breast milk and could potentially cause significant side effects in the newborn together with amplified sleepiness, breathing troubles (respiratory despair), and Dying. It's not necessarily acknowledged if promethazine can pass into your breast milk.
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INDICATIONS AND Utilization Promethazine HCl and codeine phosphate oral Resolution is a combination of codeine, an opioid agonist, and promethazine, a phenothiazine, indicated to the momentary reduction of cough and higher respiratory symptoms connected with allergy or perhaps the prevalent cold in sufferers 18 years of age and more mature. (1) (one)
If concomitant use is warranted, very carefully notice the affected person, notably through remedy initiation. Discontinue promethazine HCl and codeine phosphate oral solution if serotonin syndrome is suspected.
one)]. Instruct sufferers never to share promethazine HCl and codeine phosphate oral Resolution with Other folks also to get methods to shield promethazine HCl and codeine phosphate oral Resolution from theft or misuse.
5.21 Drug/Laboratory Take a look at Interactions Due to the fact opioid agonists may boost biliary tract force, with resultant increase in plasma amylase or lipase degrees, resolve of such enzyme levels might be unreliable for 24 hours right after administration of a dose of promethazine HCl and codeine phosphate oral Remedy.
Many research examining using promethazine in pregnancy didn't locate an Affiliation with a heightened threat of congenital anomalies. Inside the few scientific tests reporting an Affiliation, no consistent pattern of malformations was noted. The majority of the reports, both of those good and damaging, have been constrained by tiny sample measurement, recall bias website and lack of data regarding dose and timing of publicity.
2) Area the mixture within a sealable bag, empty can, or other container to prevent the drug from leaking or breaking out of a rubbish bag, or to get rid of in accordance with neighborhood state recommendations and/or laws.
Serotonin Syndrome Inform clients that promethazine HCl and codeine phosphate oral Remedy could induce a uncommon but likely existence-threatening condition resulting from concomitant administration of serotonergic prescription drugs.
Will not acquire any benzodiazepines or medicines that might cause drowsiness or sleepiness through cure with Promethazine Hydrochloride and Codeine Phosphate Oral Resolution. Question your healthcare company for a summary of these medicines if You aren't positive.